Prednisolone enhances the adaptive response to intestinal resection

GLP-2 augments the adaptive response to massive intestinal resection in rat.

To determine whether treatment with a potent protease-resistant analog of human glucagon-like peptide 2 (GLP-2) might augment the adaptive response to massive intestinal resection, rats were divided into resected, which had 75% of the midjejunoileum removed, sham-resected, and nonsurgical groups. Within each group, animals were assigned to 21 days of treatment with the drug (0.1 μg/g of the GLP...

The locally acting glucocorticosteroid budesonide enhances intestinal sugar uptake following intestinal resection in rats.

BACKGROUND AND AIMS Locally and systemically acting corticosteroids alter the morphology and transport function of the intestine. This study was undertaken to assess the effect of budesonide, prednisone, and dexamethasone on sugar uptake. METHODS Adult male Sprague Dawley rats underwent transection or resection of 50% of the middle portion of the small intestine, and in vitro uptake of sugars...

The Adaptive Response to Intestinal Oxidative Stress in Mammalian Hibernation

Intestinal Epithelial-Specific mTORC1 Activation Enhances Intestinal Adaptation After Small Bowel Resection

BACKGROUND & AIMS Intestinal adaptation is a compensatory response to the massive loss of small intestine after surgical resection. We investigated the role of intestinal epithelial cell-specific mammalian target of rapamycin complex 1 (i-mTORC1) in intestinal adaptation after massive small bowel resection (SBR). METHODS We performed 50% proximal SBR on mice to study adaptation. To manipulate...

Roles for p21 and p27 during the adaptation response to massive intestinal resection

Stehr, Wolfgang, Nicole P. Bernal, Christopher R. Erwin, Kathryn Q. Bernabe, Jun Guo, and Brad W. Warner. Roles for p21 and p27 during the adaptation response to massive intestinal resection. Am J Physiol Gastrointest Liver Physiol 290: G933–G941, 2006. First published December 8, 2005; doi:10.1152/ajpgi.00235.2005.—The magnitude of gut adaptation is a decisive factor in determining whether pat...